Anchor negatively regulates BMP signaling to control Drosophila wing 1 development 2 Running title : A novel gene anchor

Anchor negatively regulates BMP signaling to control Drosophila wing 1 development 2 Running title : A novel gene

Anchor negatively regulates BMP signaling to control Drosophila wing 1 development 2 Running title : A novel

statement: The novel gene anchor is the ortholog of vertebrate GPR155, 9 which contributes to preventing wing disc tissue overgrowth and limiting the 10 phosphorylation of Mad in presumptive veins during the pupal stage. 11. CC-BY-NC-ND 4.0 International license not peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was. ABSTRACT 12 G...

Feedback regulation of Drosophila BMP signaling by the novel extracellular protein larval translucida.

The cellular response to the Drosophila BMP 2/4-like ligand Decapentaplegic (DPP) serves as one of the best-studied models for understanding the long-range control of tissue growth and pattern formation during animal development. Nevertheless, fundamental questions remain unanswered regarding extracellular regulation of the ligand itself, as well as the nature of the downstream transcriptional ...

Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker.

Wnts and bone morphogenetic proteins (BMPs) are signaling elements that are crucial for a variety of events in animal development. In Drosophila, Wingless (Wg, a Wnt ligand) and Decapentaplegic (Dpp, a BMP homolog) are thought to function through distinct signal transduction pathways and independently direct the patterning of the wing. However, recent studies suggest that Mothers against Dpp (M...

Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements.

Imaginal disc development in Drosophila requires coordinated cellular proliferation and tissue patterning. In our studies of TGFβ superfamily signaling components, we found that a protein null mutation of Smad2, the only Activin subfamily R-Smad in the fruit fly, produces overgrown wing discs that resemble gain of function for BMP subfamily signaling. The wing discs are expanded specifically al...